Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 tablet
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
2 mg
118%
Folate (as folic acid)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41667%
Top Medical Research Studies
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We explored the intriguing case of a 56-year-old man diagnosed with Biermer's disease, also known as pernicious anemia, an autoimmune condition that leads to a lack of intrinsic factor and, consequently, vitamin B12 malabsorption. This patient presented with unusual symptoms: not just digestive concerns like melena, but also notable neurological effects such as memory issues and gait disturbances.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis鈥攊ncluding gastroscopy, ultrasound, and blood tests鈥攚e initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient鈥檚 condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
During our examination, we discovered symptoms indicative of cerebellar ataxia, along with a red and swollen limb that pointed toward deep vein thrombosis (DVT). The tests revealed severe macrocytic anemia and confirmed a deficiency in vitamin B12 while keeping folate levels normal. Following a thorough diagnosis鈥攊ncluding gastroscopy, ultrasound, and blood tests鈥攚e initiated a treatment plan that included vitamin B12 supplementation and anticoagulant therapy.
The outcome of our intervention was promising, with significant clinical improvement observed in the patient鈥檚 condition. Our findings reinforce the essential role of vitamin B12 in managing this type of autoimmune disorder, particularly when neurological and cardiovascular complications arise.
Read More
8
Vitamin B6 improves cognitive function
We conducted an intriguing study that looked into how vitamin B6 affects cognitive function in patients with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder often brings along cognitive challenges, so understanding potential dietary influences could be beneficial.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
By surveying 24 NMOSD patients at Sina Hospital in Tehran, we gathered detailed dietary habits through a comprehensive food frequency questionnaire. The cognitive abilities of participants were assessed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery, which allowed us to evaluate their mental performance thoroughly.
Our findings were particularly interesting: we observed a positive correlation between the amount of dietary vitamin B6 consumed and cognitive function. Specifically, higher intake was linked to better performance in verbal and learning memory, as well as working memory and processing speed. This suggests that boosting vitamin B6 intake might help enhance cognitive functioning in NMOSD patients, which is encouraging given the prevalence of cognitive issues in this group.
Overall, our study opens up promising pathways for dietary intervention in managing cognitive impairment related to autoimmune disorders like NMOSD.
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Most Useful Reviews
9
Effective treatment
1 people found this helpful
I received a recommendation to order this product during my first visit to the reproductologist. Tests indicated a tendency towards folic acid deficiency and elevated homocysteine levels. After a month of taking the product, my indicators improved significantly and were adjusted to the desired limits. Conclusion: this product is effective, and I plan to continue taking it regularly.
Read More
7.5
Increased calmness
If you seek calmness and stress resistance, this vitamin is ideal. I ordered it for myself and friends, and everyone noted improvements in their condition within a week of taking it. This seems to be a very good result!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.6
- All Researches
9.5
Vitamin B12 supplementation benefits autoimmune patients
We explored the impact of vitamin B12 on patients with autoimmune disorders, particularly those experiencing symptoms often attributed to their underlying conditions. The study presented three cases of individuals with neuropathic pain, depression, fatigue, and muscle weakness, who had their symptoms initially misattributed to rheumatic diseases.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Upon starting vitamin B12 supplementation, these patients showed nearly complete resolution of their symptoms, highlighting the potential benefits of this vitamin in treating related health issues. Interestingly, several participants did not display obvious deficiencies in vitamin B12 levels according to lab tests, suggesting that even those who appear to have sufficient levels could still benefit from supplementation.
Furthermore, we delved into research indicating the nerve-protective properties of vitamin B12, which could play a crucial role in managing pain and neuropathy associated with long-standing rheumatic diseases. Therefore, we recommend that healthcare providers consider checking vitamin B12 levels early in the diagnostic journey for autoimmune conditions, and think about offering supplementation regardless of laboratory findings.
Read More
9
We examined a case of a 51-year-old Ugandan man who experienced recurring lower limb weakness linked to pernicious anemia, an autoimmune condition causing vitamin B12 deficiency. After initial treatments, his symptoms reappeared, leading to further testing that confirmed the diagnosis.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Treatment with vitamin B12 injections significantly improved his condition. This case emphasizes the need for healthcare providers to recognize the signs of vitamin B12 deficiency early, particularly in resource-limited settings, to ensure timely diagnosis and treatment.
Read More
9
We examined a fascinating case of a 54-year-old man experiencing the rare overlap of Guillain-Barr茅 Syndrome (GBS) and autoimmune gastritis. After a thorough medical evaluation, which included MRI and biopsy, he was diagnosed with both GBS and a vitamin B12 deficiency linked to atrophic gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Treatment with intravenous immunoglobulin and methylcobalamin (vitamin B12) led to substantial improvement in his symptoms. This case highlights the importance of recognizing potential nutrient deficiencies, especially those impacting autoimmune disorders like GBS and autoimmune gastritis.
Read More
9
We aimed to understand how high doses of vitamins B1, B6, and B12 might help improve vision in people suffering from relapsing-remitting multiple sclerosis (RRMS) who face persistent visual loss after acute optic neuritis. In our pilot study, we included sixteen patients who had been diagnosed with RRMS and had visual disabilities resulting from an earlier bout of optic neuritis. Each participant received a daily regimen of high-dose vitamins for 90 days, alongside their regular disease-modifying therapies.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Over the three-month follow-up, we noticed a significant improvement in visual acuity and foveal sensitivity threshold, suggesting that high doses of these B vitamins could play a role in enhancing visual function. The trends for other measures, such as mean deviation and pattern standard deviation in visual testing, were also promising. We found an interesting correlation: older patients had longer latency times in their visual processing but lower visual acuity at the follow-up. Crucially, we determined that the foveal sensitivity threshold was the main predictor of visual acuity improvement.
Although vitamin B6 was part of the combination treatment, it was challenging to pinpoint its individual effects. However, the collective results indicated that high-dose vitamin B treatment can be beneficial for visual function parameters in patients with MS-related visual issues.
Read More
9
We investigated the potential benefits of a treatment composed of advanced glycation end products inhibitors, which included vitamin B6, on patients with rheumatoid arthritis (RA). The study focused on how this combination therapy could enhance endothelial function in individuals suffering from this autoimmune disorder.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
In a controlled research setup, 24 patients experiencing active RA despite standard treatments were given an AGEs inhibitor containing vitamins and other compounds. Over 12 weeks, we monitored various health indicators, including inflammatory markers and measures of endothelial function.
The results were promising. We noticed significant improvements in endothelial function, as indicated by enhanced vasodilation measures. Additionally, levels of inflammatory markers like ESR and CRP decreased notably, along with reductions in RA activity scores.
While vitamin B6 is included in the treatment mix, the study highlights the collective impact of the entire formulation on managing RA symptoms. This indicates the potential role that AGEs inhibitors, with vitamin B6 among other ingredients, can play in treating this challenging condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
1 people found this helpful
I received a recommendation to order this product during my first visit to the reproductologist. Tests indicated a tendency towards folic acid deficiency and elevated homocysteine levels. After a month of taking the product, my indicators improved significantly and were adjusted to the desired limits. Conclusion: this product is effective, and I plan to continue taking it regularly.
Read More
7.5
Increased calmness
If you seek calmness and stress resistance, this vitamin is ideal. I ordered it for myself and friends, and everyone noted improvements in their condition within a week of taking it. This seems to be a very good result!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. doi:10.59556/japi.73.0892
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Ma XY, Hao Y, Xie YH, Cao Q, Sun DF, et al. Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case-Control Study in China. J Gastroenterol Hepatol. 2025. doi:10.1111/jgh.16912
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Xiang H, Cai M. Coexistence of Guillain-Barr茅 Syndrome and Subacute Combined Degeneration of the Spinal Cord Due to Autoimmune Gastritis: A Case Report and Literature Review. Cureus. 2024;16:e63084. doi:10.7759/cureus.63084
- Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, et al. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Sci Transl Med. 2024;16:eadl3758. doi:10.1126/scitranslmed.adl3758
- Du X, Yang Y, Zhan X, Huang Y, Fu Y, et al. Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner. J Cell Mol Med. 2020;24:13129. doi:10.1111/jcmm.15917
- Mallone F, Lucchino L, Franzone F, Marenco M, Carlesimo SC, et al. High-dose vitamin B supplementation for persistent visual deficit in multiple sclerosis: a pilot study. Drug Discov Ther. 2020;14:122. doi:10.5582/ddt.2020.03031
- Rezaeimanesh N, Saeedi R, Sahraian MA, Razeghi Jahromi S, Naser Moghadasi A. The possible beneficial effects of higher vitamin B6 intake from diet on cognitive function of patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020;42:102132. doi:10.1016/j.msard.2020.102132
- Sande JS, Ulvik A, Midttun 脴, Ueland PM, Hammer HB, et al. Vitamin B-6 Status Correlates with Disease Activity in Rheumatoid Arthritis Patients During Treatment with TNF伪 Inhibitors. J Nutr. 2019;149:770. doi:10.1093/jn/nxz001
- Syngle A, Vohra K, Garg N, Kaur L, Chand P. Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis. 2012;15:45. doi:10.1111/j.1756-185X.2011.01679.x
- Han R, Zhou D, Ji N, Yin Z, Wang J, et al. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. J Nanobiotechnology. 2025;23:41. doi:10.1186/s12951-025-03096-5
- Nasra S, Bhatia D, Kumar A. Targeted Macrophage Re-Programming: Synergistic Therapy With Methotrexate and RELA siRNA Folate-Liposome in RAW264.7 Cells and Arthritic Rats. Adv Healthc Mater. 2024;13:e2400679. doi:10.1002/adhm.202400679
- Pesqueda-Cendejas K, Parra-Rojas I, Campos-L贸pez B, Mora-Garc铆a PE, Ruiz-Ballesteros AI, et al. Association of c.+677 C>T (rs1801133) and c.+1298 A>C (rs1801131) genetic variants with cardiometabolic and disease risk in systemic lupus erythematosus patients: A cross-sectional study. Lupus. 2024;33:918. doi:10.1177/09612033241257158
- Avalos-Salgado FA, Gonzalez-Lopez L, Gonzalez-Vazquez S, Ponce-Guarneros JM, Santiago-Garcia AP, et al. Risk Factors Associated with Adverse Events Leading to Methotrexate Withdrawal in Elderly Rheumatoid Arthritis Patients: A Retrospective Cohort Study. J Clin Med. 2024;13. doi:10.3390/jcm13071863
- Patel AV, Morgan SL, Green R, Danila MI, Merriman TR, et al. Vitamin B12 status and hyperhomocysteinemia in patients with Rheumatoid arthritis treated with methotrexate and folic acid. Am J Med Sci. 2024;368:33. doi:10.1016/j.amjms.2024.03.020
- Wells L, O'Hara N, Frye RE, Hullavard N, Smith E. Folate Receptor Alpha Autoantibodies in the Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) Population. J Pers Med. 2024;14. doi:10.3390/jpm14020166
- Subtil J, Carvalho R, Rebelo AF, Subtil P. Autoimmune Polyglandular Syndrome Type 3: A Case Report. Cureus. 2024;16:e76152. doi:10.7759/cureus.76152
- Mansour M, Shamasnah A, Alsaadi D, Abu Saif S, Krama A. Evans syndrome as a presentation in systemic lupus erythematous, coexisting with Hashimoto's thyroiditis and pernicious anemia: a case report. J Med Case Rep. 2024;18:643. doi:10.1186/s13256-024-05002-3
- Hijjawi N, Tout FS, Azaizeh B, Aljaafreh B. The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review. Clin Rheumatol. 2025;44:591. doi:10.1007/s10067-024-07285-9
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Fernandez I, Touzot F. Looking for ALPS: The value of a combined assessment of biochemical markers. Pediatr Allergy Immunol. 2024;35:e14135. doi:10.1111/pai.14135
- Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, et al. Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. J Neurovirol. 2024;30:197. doi:10.1007/s13365-024-01203-0
- Yang CW, Hsu HY, Lee YZ, Lee SJ. Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice. Biochem Biophys Res Commun. 2024;704:149668. doi:10.1016/j.bbrc.2024.149668
- Du艂ak NA, Rytlewska M, Jask贸lska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
